ALTERING AN IMMUNE RESPONSE BY INFLUENCING THE INTERACTION OF LAIR WITH ITS LIGAND

摘要

The invention provides a method to modulate the interaction between a LIAR and its ligand, said ligand being EP-CAM or a functional equivalent thereof, comprising providing EP-CAM or a functional equivalent thereof, or providing an EP-CAM antagonist. Preferably, said LAIR is part of an immune cell. With a method of the invention it is possible to modulate LAIR-induced 'silencing' of immune cells. In one aspect the invention provides a compound capable of at least in part reducing the LAIR-induced 'silencing' of immune cells. Use of an EP-CAM, an EP-CAM antagonist, and/or a functional equivalent thereof for modulating the LAIR-induced 'silencing' of immune cells is also provided.