INTEGRIN LINKED KINASE MODULATION OF LEUKOCYTE TRAFFICKING

摘要

Methods are provided to specifically modulate the trafficking of leukocytes that signal through the integrin linked kinase. Agonists or other agents that enhance ILK function increase leukocyte accumulation at a targeted site. In an alternative embodiment, the agent is an antagonist that blocks ILK biological activity and decreases leukocyte accumulation. The methods of the invention manipulate the integrin mediated signaling during trafficking to affect the localization of immune effector cells in targeted tissues.