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SYSTEMS AND METHODS FOR PREDICTING ACTIVE SITE RESIDUES IN A PROTEIN
SYSTEMS AND METHODS FOR PREDICTING ACTIVE SITE RESIDUES IN A PROTEIN
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机译:预测蛋白质中活性位点残基的系统和方法
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摘要
A system and method for predicting the active site residues in a target protein. The target protein, referred to interchangeably as the target amino sequence or the target sequence, is pairwise aligned with a set of query sequences. Using these multiple pairwise sequence alignments, residue positions within the target sequence which satisfy specified sequence-based criteria are identified as candidate active site positions. Candidate active site positions are mapped to a three-dimensional representation of the target sequence and filtered against structure-based criteria. Positions within the target sequence that satisfy both the sequence-based and structure-based criteria are predicted to be active site residues.
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