VACCINES AGAINST KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS

摘要

CD8 T cell epitopes derived from Kaposi's sarcoma herpesvirus (KSHV) have the formula (I): X1X2X3X4X5X6X7X8X9X10X11X12X13X14X15 wherein - X1 is E, X2 is L, X3 is T, X4 is D, X5 is A, X6 is L, X7 is I, X8 is S, X9 is A, X10 is F, X11 is S, X12 is G, X13 is S, X14 is Y and X15 is S; - X1 is L, X2 is I, X3 is L, X4 is Y, X5 is L, X6 is C, X7 is V, X8 is P, X9 is R, X10 is C, X11 is R, X12 is R, X13 K, X14 K and X15 is P; - X1 is G, X2 is H, X3 is R, X4 is Q, X5 is S, X6 is I, X7 is W, X8 is I, X9 is T, X10 is W, X11 is R, X12 is A, X13 is Q, X14 is P and X15 is V; - X1 is R, X2 is A, X3 is Q, X4 is P, X5 is V, X6 is L, X7 is Q, X8 is T, X9 is L, X10 is C, X11 is A, X12 is Q, X13 is P, X14 is S and X15 is N; or - X1 is T, X2 is A, X3 is T, X4 is A, X5 is A, X6 is G, X7 is L, X8 is S, X9 is L, X10 is S, X11 is S, X12 is I, X13 is Y, X14 is L and X15 is G. Polypeptides comprising an epitope sequence and polynucleotides encoding such polypeptides are useful for vaccinating a host against KSHV infection.