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NOVEL PLATINUM (IV) COMPLEXES, PROCESS FOR PRODUCING THE SAME, AND CARCINOSTATIC AGENTS CONTAINING THE SAME
NOVEL PLATINUM (IV) COMPLEXES, PROCESS FOR PRODUCING THE SAME, AND CARCINOSTATIC AGENTS CONTAINING THE SAME
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机译:新型铂(IV)配合物,制备方法和包含该试剂的抗癌剂
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摘要
A platinum(IV) complex represented by the general formula (I): CHEM wherein R1 and R2 independently represent ammonia, an alkylamine or a cycloalkylamine, or R1 and R2 may together form a cycloalkyldiamine; X1 and X2 independently represent a halogen, nitrate ion, sulfate ion or a monocarboxylic acid, or X1 and X2 may together form a glycolate or a dicarboxylic acid; Y1 represents formic acid, a C1-C8 alkyl-, alkenyl-, aryl-, aralkyl-, alkylamino- or alkoxyl-monocarboxylic acid or sulfonic acid; and Y2 represents a halogen. The complex of the invention is stable even when orally administered and has high antitumor activity.
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机译:通式(I)表示的铂(IV)配合物:其中R1和R2独立地代表氨,烷基胺或环烷基胺,或R1和R2可以一起形成环烷基二胺。 X1和X2独立地表示卤素,硝酸根离子,硫酸根离子或一元羧酸,或者X1和X2可以一起形成乙醇酸酯或二羧酸; Y 1代表甲酸,C 1 -C 8烷基-,烯基-,芳基-,芳烷基-,烷基氨基-或烷氧基-单羧酸或磺酸; Y 2表示卤素。本发明的复合物即使口服给药也稳定并且具有高抗肿瘤活性。
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