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PREPARATION OF TRIPHOSPHOSRYLATED ORGANIC COMPOUNDS OPTIONALLY MARKED WITH PHOSPHORUS 32 OR PHOSPHORUS 33
PREPARATION OF TRIPHOSPHOSRYLATED ORGANIC COMPOUNDS OPTIONALLY MARKED WITH PHOSPHORUS 32 OR PHOSPHORUS 33
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机译:可选用磷32或磷33标记的三磷酸有机化合物的制备
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摘要
The invention concerns a method for preparing a triphosphorylated organic compound from a monophosphorylated or diphosphorylated compound in the presence of phosphate ions and using dicyclohexylcarbodiimide (DCC) as condensation activating agent. The reaction mixture comprises at least 30 % by volume of DMSO and/or DMF and/or TMS. The organic compound can be a mono- or diphosphate thiamine, a mono- or diphosphate adenosine or a mono-or diphosphate nucleoside or deoxynucleoside. The reaction mixture advantageously comprises pyridine. In accordance with particularly advantageous embodiments of the invention, the triphosphorylated derivatives are marked with p?32 and p33¿ in gamma or alpha position.
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