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Use of hyaluronic acid for the preparation of an aqueous solution useful as intra-articular lavage liquid

机译:透明质酸在制备用作关节内灌洗液的水溶液中的用途

摘要

Described herein is the use of hyaluronic acid or of one of its pharmaceutically acceptable salts for the preparation of a formulation for intra-articular irrigation, in the form of an aqueous solution, comprising hyaluronic acid having molecular weight of between 0.5 and 5.0 million daltons or one of its pharmaceutically acceptable salts, in a concentration of between approximately 0.1% and approximately 0.9% weight/volume, and preferably one or more cationic species chosen from among sodium, potassium, calcium and magnesium, and one or more anionic species chosen from among chloride ions, phosphate ions and citrate ions.
机译:本文描述了透明质酸或其药学上可接受的盐之一在制备用于关节内冲洗的水溶液形式的制剂中的用途,所述水溶液包含分子量为0.5至500万道尔顿的透明质酸或一种其药学上可接受的盐,其浓度在约0.1%至约0.9%重量/体积之间,并且优选一种或多种选自钠,钾,钙和镁的阳离子物种,以及一种或多种选自以下的阴离子物种:氯离子,磷酸根离子和柠檬酸根离子。

著录项

  • 公开/公告号EP0875248B1

    专利类型

  • 公开/公告日2003-03-05

    原文格式PDF

  • 申请/专利权人 TRB CHEMEDICA S.A.;

    申请/专利号EP19980107889

  • 发明设计人 DI NAPOLI GUIDO;

    申请日1998-04-28

  • 分类号A61K31/728;A61P19/02;

  • 国家 EP

  • 入库时间 2022-08-21 23:53:48

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