METHODS AND COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE BY CO-ADMINISTERING A CHEMOKINE WITH AN ANTIGEN

摘要

Method for inducing an immune response by administering a composition containing an antigen and an antigen-presenting cell (APC) chemotaxin or a cell expressing an antigen-presenting cell chemotaxin. The APC chemotaxin is chemotactic for dendritic cells. In vitro and in vivo chemotaxis assays were carried out with MCP2, MCP3, MIP1b, MIP3a, MIP3beta, RANTES, mMIG, mMDC, mC10, vMIP1. An increased antibody response upon vaccination of monkeys with ovalbumine and mC10 or vMCK-2 was shown.