Methods are disclosed for combating bio-terrorism. More specifically, methods are disclosed for combating bio-terrorism by irradiating a material, such as a letter or package or currency, to reduce the level of one or more biological contaminants or pathogens that may be present on or in the material, such as viruses, bacteria (including inter- and intracellular bacteria, such as mycoplasmas, ureaplasmas, nanobacteria, chlamydia, rickettsias), yeasts, molds, fungi, single or multi-cellular parasites, and/or prions or similar agents responsible, alone or in combination, for TSEs.
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