ENANTIOSELECTIVE HYDROXYLATION OF BETA-DICARBONYLS CATALYZED BY CINCHONA ALKALOID DERIVATIVES

摘要

The present invention pertains to a process for preparing a compound of Formula I that is enantiomerically enriched at the chiral hydroxylation center indicated by Formula (I) comprising contacting a compound of Formula (II) with an oxidant in the presence of a chiral compound of Formula III or ent-III, wherein R?1, R2 and R3¿ are as defined in the disclosure.