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AQUEOUS PROCESS FOR MANUFACTURING PAROXETINE SOLID DISPERSIONS
AQUEOUS PROCESS FOR MANUFACTURING PAROXETINE SOLID DISPERSIONS
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机译:制备帕罗西汀固体分散体的水性工艺
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摘要
A process for preparing solid, amorphous paroxetine comprising: (A) mixing paroxetine free base or a pharmaceutically acceptable paroxetine salt with water and pharmaceutically acceptable polymer; and (B) drying to form a composition comprising amorphous paroxetine and polymer, eliminating the need for organic solvents common for the solvent process. The resultant amorphous solid paroxetine composition is free from crystalline form, and yet has good handling properties, making it suitable for pharmaceutical use in the traditional tablet dosage form.
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