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CRYSTALLIZED DnaG PRIMASE COMPLEXES AND METHODS OF USE THEREOF

机译：结晶的DnaG蛋白酶复合物及其使用方法

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摘要

The present invention provides crystals of a Staphylococcus aureus DnaG primase and Escherichia coli DnaG primase proteins complexed with ligands. The three-dimensional structural information for Staphylococcus aureus DnaG primase with magnesium bound, Staphylococcus aureus DnaG primase with sulfate bound, and Escherichia coli DnaG primase with manganese bound is provided. The present invention provides procedures for identifying agents that can inhibit the cell growth of Staphylococcus aureus, Escherichia coli, or both through the use of rational drug design utilizing the crystallographic data.

机译：本发明提供了与配体复合的金黄色葡萄球菌DnaG引发酶和大肠杆菌DnaG引发酶蛋白的晶体。提供了与镁结合的金黄色葡萄球菌DnaG primase，与硫酸盐结合的金黄色葡萄球菌DnaG primase和与锰结合的大肠杆菌DnaG primase的三维结构信息。本发明提供了通过使用利用晶体学数据的合理药物设计来鉴定可抑制金黄色葡萄球菌，大肠杆菌或两者的细胞生长的试剂的方法。

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公开/公告号WO03060100A2

专利类型
公开/公告日2003-07-24

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CUMBRE INC.;BERGER JAMES M.;KECK JAMES;LYNCH A. SIMON;CHU CLEMENT;
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申请/专利号WO2003US00820
发明设计人 BERGER JAMES M.;KECK JAMES;LYNCH A. SIMON;CHU CLEMENT;
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申请日2003-01-13
分类号C12N;
国家 WO
入库时间 2022-08-21 23:52:13

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