Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides (I) involves converting a 3,5-dimethyl-benzoic acid (V) into the acid chloride (IV), subjecting the side-chains to radical chlorination, fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride and reacting with silicon tetrachloride in presence of another Lewis acid. Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides of formula (I) involves: (1) converting a 3,5-dimethyl-benzoic acid of formula (V) into the corresponding acid chloride of formula (IV); (2) subjecting the side-chains to complete radical chlorination to give a 3,5-bis-(trichloromethyl)-benzoyl chloride of formula (III); (3) fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride of formula (II); and (4) reacting with silicon tetrachloride in presence of another Lewis acid. [Image] X : H, F or Cl. Independent claims are included for the intermediates (III; X = F or Cl) and (IV; X = F or Cl) as new compounds.
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机译:3,5-双-(三氟甲基)-苯甲酰氯(I)的制备包括将3,5-二甲基-苯甲酸(V)转化为酰氯(IV),对侧链进行自由基氯化,并用用无水氟化氢和/或五氟化锑得到3,5-双-(三氟甲基)-苯甲酰氟,并在另一路易斯酸的存在下与四氯化硅反应。式(I)的3,5-双-(三氟甲基)-苯甲酰氯的制备包括:(1)将式(V)的3,5-二甲基-苯甲酸转化为相应的式(IV)的酰氯; (2)使侧链完全进行自由基氯化,得到式(III)的3,5-双-(三氯甲基)-苯甲酰氯; (3)用无水氟化氢和/或五氟化锑氟化,得到式(II)的3,5-双-(三氟甲基)-苯甲酰氟; (4)在另一路易斯酸的存在下与四氯化硅反应。 [图像] X:H,F或Cl。作为新化合物的中间体(III; X = F或Cl)和(IV; X = F或Cl)包括独立权利要求。
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