SUBSTITUTED 1,3,4-OXADIAZOLES AND A METHOD OF REDUCING TNF-ALPHA LEVELS

摘要

Substituted 1,3,4-oxadiazole compounds reduce the levels of TNF alpha in a mammal. Typical embodiments are 2-Ä1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(1,3,4-oxadiazol-2-yl)ethylÜ-5-methylisoindoline-1,3-dione and 2-Ä1-(3-ethoxy-4-methoxyphenyl)-2-(1,3,4-oxadiazol-2-yl)ethylÜisoindoline-1,3-dione.