USE OF P-SELECTIN GLYCOPROTEIN LIGAND-1 (PSGL-1) AND FRAGMENTS THEREOF FOR THE INHIBITION OF THROMBOSIS

摘要

The present invention relates to methods and compositions for the modulation of thrombosis, in a subject, by administering a P-selectin antagonist. The invention further provides methods for modulating leukocyte recruitment, cellular migration, leukocyte rolling velocity, intercellular adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand or fragments thereof, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. The invention also provides methods for identifying compounds capable of modulating thrombosis.