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Use of P-selectin glycoprotein ligand-1 (PSGL-1) and fragments thereof for the inhibition of thrombosis
Use of P-selectin glycoprotein ligand-1 (PSGL-1) and fragments thereof for the inhibition of thrombosis
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机译:P-选择蛋白糖蛋白配体-1(PSGL-1)及其片段在抑制血栓形成中的用途
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摘要
The present invention relates to methods and compositions for the modulation of thrombosis, in a subject, by administering a P-selectin antagonist. The invention further provides methods for modulating leukocyte recruitment, cellular migration, leukocyte rolling velocity, intercellular adhesion, and cell adhesion to blood vessels in a subject by administering soluble P-selectin ligand or fragments thereof, an anti-P-selectin ligand antibody, or an anti-P-selectin antibody. The invention also provides methods for identifying compounds capable of modulating thrombosis.
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