Described herein is the identification of two polymorphic isoforms of the gene encoding the PTHrP protein, of the allelic proteins, of a first polynucleotide comprising the polymorphic domain corresponding to SEQ ID NO: 2 and comprising a first polymorphic position, of a second polynucleotide comprising a second polymorphic domain and corresponding to SEQ ID NO: 7 which encode for two variants of the PTHrP protein; also described is the use of these genes, alleles or polynucleotides to determine the risk of tumor in animals and humans and genetically modified cells and non-human animals.
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机译:本文描述了编码PTHrP蛋白的基因,等位基因蛋白,包含对应于SEQ ID NO:2的多态性结构域并包含第一多态性位置的第一多核苷酸的两个多态性同工型的鉴定,以及包含PTHrP蛋白的第二多核苷酸。第二多态结构域并对应于编码PTHrP蛋白的两个变体的SEQ ID NO:7;还描述了使用这些基因,等位基因或多核苷酸确定动物和人类以及转基因细胞和非人类动物患肿瘤的风险。
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