Use of dehydroepiandrosterone and an estradiol derivative for preparing a medicament for treating postmenopausal climacteric disorders

摘要

A medicament (A) for treating climacteric disorders, as a result of simultaneous post-menopausal estrogen and androgen deficiency, comprises: (1) an estra-1,3,5(10),8-tetraene-3,17alpha-diol steroid (I); and (2) one or more of dehydroepiandrosterone (DHEA) and its esters or other derivatives. A medicament (A) for treating climacteric disorders, as a result of simultaneous post-menopausal estrogen and androgen deficiency, comprises: (1) an estra-1,3,5(10),8-tetraene-3,17alpha-diol steroid of formula (I); and (2) one or more of dehydroepiandrosterone (DHEA) and its esters or other derivatives. R = H or 1-4C alkyl; R1, R2 = H; or R1 + R2 = CH2.