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Screening method for agents against cardiovascular diseases

机译:心血管疾病药物的筛选方法

摘要

The present invention relates to a method to identify potential drugs for treating or preventing diseases of the cardiovascular system in humans and animals, which method comprises culturing a living avian embryo; incubating said avian embryo with at least one first compound or composition, said at least one first compound or composition causing a detectable change in the activity of the cardiovascular system of said avian embryo; incubating said avian embryo with at least one second compound or composition, said at least one second compound or composition being to be tested as a potential drug; and detecting and/or monitoring an effect of said at least one second compound or composition and/or said at least one first compound or composition on the cardiovascular system of said bird embryo.
机译:本发明涉及鉴定用于治疗或预防人和动物的心血管系统疾病的潜在药物的方法,该方法包括培养活的禽类胚胎。用至少一种第一化合物或组合物孵育所述禽类胚胎,所述至少一种第一化合物或组合物引起所述禽类胚胎的心血管系统活性的可检测的变化;将所述禽类胚胎与至少一种第二化合物或组合物一起温育,所述至少一种第二化合物或组合物将作为潜在药物进行测试;检测和/或监测所述至少一种第二化合物或组合物和/或所述至少一种第一化合物或组合物对所述鸟胚胎的心血管系统的作用。

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