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A THERAPEUTIC AGENT CONTAINING CELASTROL CELAPHANOL SESQUITERPENE ESTER OR AN EXTRACT OF CELASTRUS OBICULATUS AS AN EFFECTIVE INGREDIENT FOR THE TREATMENT OF INFLAMMATORY DISEASE IMMUNE DISORDERS OR CANCERS
A THERAPEUTIC AGENT CONTAINING CELASTROL CELAPHANOL SESQUITERPENE ESTER OR AN EXTRACT OF CELASTRUS OBICULATUS AS AN EFFECTIVE INGREDIENT FOR THE TREATMENT OF INFLAMMATORY DISEASE IMMUNE DISORDERS OR CANCERS
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机译:含有西乐白藜芦醇倍半萜烯酯或沙棘母提取物的治疗剂,作为治疗炎症性疾病免疫疾病或癌症的有效成分
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摘要
PURPOSE: A therapeutic agent for inflammatory disease, immune disease and cancer which contains celastrol, celaphanol, a sesquiterpene ester-based compound or a Celastrus orbiculatus Thunb. extract as effective ingredient is provided. The Celastrus orbiculatus Thunb. extract containing the celastrol also can be used as an NF-B inhibitor. CONSTITUTION: An NF-B inhibitor contains celastrol of the formula(1), celaphanol of the formula(2) and a sesquiterpene ester-based compound of the formula(3). In formulae, R1 is H, furoic acid or benzoic acid, R3 is H or acetic acid and R4 is furoic acid or benzoic acid. The NF-B inhibitor also contains a Celastrus orbiculatus Thunb. extract containing the celastrol. The Celastrus orbiculatus Thunb. extract is obtained by extracting in C1-4 alcohol, followed by reextraction in an organic solvent, separation and then purification. The therapeutic agent for inflammatory disease, immune disease and cancer contains the celastrol, celaphanol, sesquiterpene ester-based compound or Celastrus orbiculatus Thunb. extract.
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