- -METHYL BAYLIS-HILLMAN ADDUCTS AND METHOD FOR THE PREPARATION THEREOF USING THE INDIUM METAL

摘要

PURPOSE: Provided is a method of making -methyl substituted Baylis-Hillman product represented by the formula(1) with indium easily under mild condition. The product is useful as precursor for the synthesis of carbapenem antibiotics. CONSTITUTION: A method of preparation of making -methyl substituted Baylis-Hillman product comprises the steps of: making a compound of the formula (IV) by mixing and reacting a compound of the formula (II) with a compound of the formula(III) in a solvent, followed by addition of indium, stirring, reacting with acid and extraction; and adding the compound of the formula(IV) and base. In the formula (IV), R is alkyl, cycloalkyl, aryl or heterocyclic compound; R1 is alkyl, aryl or heterocyclic compound.