AGENT FOR TREATING TYPE B HEPATITIS CONTAINING PHYLLANTHUS URINARIA AND PRODUCTION THEREOF

摘要

PURPOSE: A method of preparing an agent for treating Type B hepatitis using an extract of Phyllanthus ussuriensis or Phyllanthus urinaria is provided. By the administration of the Phyllanthus ussuriensis extract to a patient suffering from Type B hepatitis, HBV-DNA is detected to be negative within 3 months after the administration thereof and medical findings of transaminase have been improved. CONSTITUTION: An agent for treating type B hepatitis comprises an extract of Phyllanthus ussuriensis or Phyllanthus urinaria and an excipient containing microcrystalline cellulose, hydroxypropyl cellulose or magnesium stearate. Phyllanthus ussuriensis or Phyllanthus urinaria is washed with water, cut into 1 to 2cm, washed with purified water at 30 to 40deg.C and extracted with 20 times of purified water at 93deg.C for 10hr. Thereafter, the extract is filtered, concentrated at 45deg.C for 4hr in a vacuum concentrator, cooled to -70deg.C or less for 24hr and freeze-dried at -15 to -75deg.C after centrifugation.