Aniline derivatives with nitric oxide synthase inhibition

摘要

Compounds represented by the formula (1) or their possible stereoisomers, optically active agents and their acceptable salts as medicaments thereof:;(Wherein R ₁ represents SR ₆ or NR ₇ R ₈ ; R ₆ represents an alkyl group having 1 to 6 carbon atoms; R ₇ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or a nitro group; R ₈ represents a hydrogen atom or carbon number) R ₂ and R ₃ each represent a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, etc. R ₄ represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, or an amine moiety to be substituted with an alkyl group or nitro group. R ₅ represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms; Y ₁ , Y ₂ , Y ₃ , Y ₄ may be the same or different, and each represents a hydrogen atom, a halogen atom, or a carbon atom. An alkoxy group of -6, etc., n and m each represent an integer of 0 or 1). Since the compound has a potent nitric oxide synthase inhibitory effect, it is useful as a cerebrovascular disorder therapy.