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POLYMER CONJUGATE OF RECOMBINANT HUMAN SUPEROXIDE DISMUTASE(RHSOD) AND PREPARATION METHOD THEREOF
POLYMER CONJUGATE OF RECOMBINANT HUMAN SUPEROXIDE DISMUTASE(RHSOD) AND PREPARATION METHOD THEREOF
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机译:重组人超氧化物歧化酶(RHSOD)的聚合物缀合物及其制备方法
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摘要
PURPOSE: A polymer conjugate of recombinant human superoxide dismutase(rhSOD) and a preparation method thereof are provided, thereby increasing the half life of rhSOD, and maintaining the activity thereof. CONSTITUTION: A method for preparing the recombinant human superoxide dismutase(rhSOD) comprises the steps of: (1) oxidizing a hydroxy group of polyethylene glycol(PEG) or methoxy polyethylene glycol(mPEG) having the molecular weight of 4,000 to 8,000 to form a carboxyl derivative; (2) treating the carboxyl derivative with trimethylacetylchloride to activate the carboxyl derivative; and (3) bonding the activated derivative with a lysine residue of the recombinant human superoxide dismutase(rhSOD) via amide bonding.
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