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SOLID LIPID NANOPARTICLE AS A GENE OR DRUG CARRIER, FORMULATION, AND METHOD FOR PREPARATING THEREOF
SOLID LIPID NANOPARTICLE AS A GENE OR DRUG CARRIER, FORMULATION, AND METHOD FOR PREPARATING THEREOF
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机译:作为基因或药物载体的固体脂质纳米颗粒,制剂及其制备方法
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摘要
The present invention relates to oil-in-water lipid emulsions composed of non-triglyceride oils and solid lipid nanoparticles (SLN) composed of triglyceride or ethyl stearate used as gene transfection agents and drug delivery systems and method for preparing thereof. The present invention also concerns the method of transferring genes or drugs efficiently into cells by using the lipid emulsions and solid lipid nanoparticles. Also the present invention relates to the method of preparing lipid emulsions containing lipophilic or amphiphilic drugs by using squalene or squalane as the core-oil. The present invention also concerns the method of preparing the solid lipid nanoparticles containing lipophilic or amphiphilic drugs by using ethyl stearate as the core-fat.
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