Method for preparing of chiral compound by asymmetric ring opening reactions of epoxides

摘要

PURPOSE: Provided is a process for producing a chiral compound by using an enantioselective ring-opening reaction of epoxides in the presence of a chiral salen metal catalyst, which can recover or reuse the chiral salen metal catalyst. CONSTITUTION: The chiral compound is produced by using the enantioselective ring-opening reaction of epoxides in the presence of a salt represented by the formula 1 and the chiral salen metal catalyst represented by the formula 3. In the formula 1, when X is nitrogen, Z is -C(R5)-, R1 and R2 are each C1-C18 alkyl, R3-R5 are each hydrogen or C1-C18 alkyl and when X is carbon, Z is -C(R5)-C(R6)-, R1 is C1-C18 alkyl, R2-R6 are each hydrogen or C1-C18 alkyl, n is an integer of 1-3, and Y- is an anion capable of forming a salt. In the formula 3, R1-R4 are independently hydrogen, alkyl, carboxyl, aryl, and substituted aryl, X1-X8 are independently hydrogen, halogen, alkyl, silyl, silyloxy, alkenyl, and etc., Y1 and Y2 are each hydrogen and alkyl, M is a metal, and A is an anion.