POLYNUCLEOTIDE SEQUENCE ENCODING PROTOCADGERINE PC3, PC4, PC5 (VARIANTS), PROTOCADGERINE POLYPEPTIDE PC3, PC4, PC5 (VARIANTS)

摘要

FIELD: molecular biology, genetic engineering, biotechnology, medicine. SUBSTANCE: polynucleotide sequence encoding human protocadgerine is isolated from DNA library of human fetus brain and subjected for sequencing. Variants of human protocadgerine are designated as pc3 and pc4. Polynucleotide sequence encoding rat protocadgerine is isolated from rat DNA library, sequenced and designated as pc5. Protocadgerines show properties of proteins of intercellular adhesion. Invention allows to obtain protocadgerines by recombinant way. Invention can be used for development of therapeutic and diagnostic agents. EFFECT: improved method of preparing, valuable medicinal properties. 18 cl, 3 dwg, 2 tbl