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New acyclic or cyclic organophosphorus compounds, are gamma-delta-T cell activators useful e.g. as medicaments for treating asthma, chronic bronchitis, ulcerative colitis, autoimmune diseases or allergies
New acyclic or cyclic organophosphorus compounds, are gamma-delta-T cell activators useful e.g. as medicaments for treating asthma, chronic bronchitis, ulcerative colitis, autoimmune diseases or allergies
Organophosphorus compounds (I), including acyclic and cyclic phosphates, pyrophosphates, triphosphates, phosphonates and phosphinates, are new. Organophosphorus compounds of formula (I) are new. R1 = Me, CHO, optionally substituted hydroxymethyl or CH2R31; R31 = OH, optionally substituted phosphate or optionally substituted pyrophosphate; R33 = H, optionally substituted phosphate or optionally substituted pyrophosphate; R3 = H, optionally substituted 1-26C alkyl, optionally substituted 1-26C hydroxyalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted 2-26C alkenyl, optionally substituted 2-26C alkynyl, optionally substituted cycloalkyl, optionally substituted heterocyclyl, optionally substituted phosphate, silyl, nucleoside, nucleoside mon-, di- or triphosphate, deoxynucleotide, cation of an (in)organic base (especially a Group I-III non-transition metal, optionally substituted ammonium, ethylene diamine-derived or aminoacid-derived cation) or OR34; R34 = as R3; X1 = O or -C(Y1)(Y2)-; X2 = OR6, -X3-P(O)(OR7)(OR8), -Z1-P(O)(OR4)-X3 or a group as defined for X1 or forming a ring with C1; X3 = -Z2-P(O)(OR5)-X4 or a group as defined for X1 or forming a ring with C1; R4, R5 = as R3; R7, R8 = as R34; Z1, Z2 and X4 (forming a ring with C1) = as X1; R2 = H, OH, alkoxy, phenoxy, benzyloxy, optionally substituted phosphate or optionally substituted pyrophosphate; X2 = O or -C(Y1)(Y2)-; and Y1, Y2 = H, OH, halo, NH2, 1-9C alkoxy or 1-9C alkylthio; or together form =O. Provided that: (1) a double bond is optionally presence between C1 and C2 or C2 and C3; and (2) R31 and R3 are not simultaneously present in the molecule. AN Independent claim is included for the preparation of (I).
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