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Pure (2E)-2-(hydroxyphenyl)-2-(alkoxyimino)-N-methyl-acetamide preparation in high yield, for use as pesticide intermediate, by reacting benzofuran-2,3-dione-3-oxime with methylamine then alkylating agent
Pure (2E)-2-(hydroxyphenyl)-2-(alkoxyimino)-N-methyl-acetamide preparation in high yield, for use as pesticide intermediate, by reacting benzofuran-2,3-dione-3-oxime with methylamine then alkylating agent
Preparation of (2E)-2-(hydroxyphenyl)-2-(alkoxy- or fluoroalkoxy-imino)-N-methyl-acetamides (I) involve: (1) reacting benzofuran-2,3-dione-3-oxime (II) with methylamine (or its acid addition complex); and (2) reacting the obtained O-unsubstituted oxime (III) with an alkylating agent. Preparation of (2E)-2-(hydroxyphenyl)-2-(alkoxyimino)-N-methyl-acetamides of formula (I) involves: (1) reacting benzofuran-2,3-dione-3-oxime of formula (II) with methylamine (or its acid addition complex), optionally in presence of a diluent and/or an acid acceptor; and (2) reacting the obtained O-unsubstituted oxime of formula (III) with an alkylating agent of formula R-X (IV), optionally in presence of a diluent, acid acceptor and/or phase transfer catalyst. R = 1-6C alkyl (optionally substituted by 1-3 F); X = Cl, Br, I, OCOOR, OSO2R or OSO2OR.
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机译：（2E）-2-（羟苯基）-2-（烷氧基-或氟代烷氧基-亚氨基）-N-甲基-乙酰胺的制备（I）涉及：（1）使苯并呋喃-2,3-二酮-3-肟反应（II） ）与甲胺（或其酸加成络合物）; （2）使所得的O-未取代的肟（III）与烷基化剂反应。式（I）的（2E）-2-（羟苯基）-2-（烷氧基亚氨基）-N-甲基-乙酰胺的制备包括：（1）使式（II）的苯并呋喃-2,3-二酮-3-肟反应与甲胺（或其酸加成络合物），可选地在稀释剂和/或酸受体的存在下; （2）使获得的式（III）的O-未取代的肟与式R-X（IV）的烷基化剂反应，任选地在稀释剂，酸受体和/或相转移催化剂的存在下进行。 R = 1-6C烷基（可选地被1-3 F取代）; X = Cl，Br，I，OCOOR，OSO2R或OSO2OR。
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