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Identifying macrocyclic polyketides, useful e.g. as cytostatic agents, using biosensor cells containing reporter gene controlled by polyketide responsive promoter
Identifying macrocyclic polyketides, useful e.g. as cytostatic agents, using biosensor cells containing reporter gene controlled by polyketide responsive promoter
Identifying macrocyclic polyketides (I) by exposing (I), or a mixture containing them, to a biosensor, is new. Independent claims are also included for the following: (1) host cell (A) that contains a reporter gene (RG) under transcriptional control of a promoter that is regulatable by (I); (2) use of (A) for identifying (I); and (3) DNA construct containing an RG under transcriptional control of a promoter that is regulatable by (I).
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