Production of enolates of substituted alpha-ketoesters, comprises reaction of oxalic acid diesters with CH acid compounds in the presence of alcoholates using a 4-8C ether solvent

摘要

Production of enolates of substituted alpha -ketoesters comprises reaction of oxalic acid diesters with CH acid compounds in the presence of alcoholates using a 4-8C ether solvent. Production of enolates of substituted alpha -ketoesters of formula (I) comprises reaction of oxalic acid diesters of formula (II) with CH acid compounds of formula (III) in the presence of alcoholates of formula MOR5 (4) using a 4-8C ether solvent. R1, R2 = H, COOR, C(O)R, CN, CONHR or CONR2; R = 1-20C alkyl (optionally branched or cyclic), 6-10C aryl or an aralkyl having an R group (alkyl and aryl groups are optionally substituted by heteroatoms); R3, R4 = R; M = alkali or alkaline earth metal; and R5 = alcoholic residue of an optionally branched or cyclic aliphatic 1-6C monoalcohol; Provided that both R1 and R2 are not H.