Use of the orphan receptor TR4 and related compounds, for diagnosis and treatment of tumors and blood diseases, especially leukemia, and for drug screening

摘要

Use of TR4 (an orphan receptor), its activators, inhibitors and/or associated molecules (collectively (A)) for diagnosis, prophylaxis, monitoring, and/or (follow-up) treatment of tumors and/or diseases of the blood; proliferation, differentiation and/or expansion of hematopoietic cells, blood cells, pluripotent or committed stem cells; preparation of myeloid precursor cells or screening for pharmaceuticals. An Independent claim is also included for the use of TR4 and/or associated molecules for identification and/or isolation of TR (ant)agonists.