Genetic vaccine against leishmania major

摘要

The invention relates to a DNA-expression construct for treatment of infections with leishmaniasis and a corresponding vaccine. The above serves for immunization against leishmaniasis, whereby the immunogene p36/LACK antigen is used to generate an immunoresponse. A linear double-stranded covalently closed expression cassette is used as gene transport. According to the invention, the gene expression construct can be covalently bonded to an oligopeptide to increase the transfection efficiency.