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kainate binding, human receptors of the central nervous system (cns), from the eaa4 (excitatory amino acid) family
kainate binding, human receptors of the central nervous system (cns), from the eaa4 (excitatory amino acid) family
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机译:海藻酸酯结合,来自eaa4(兴奋性氨基酸)家族的中枢神经系统(cns)的人类受体
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摘要
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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