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Kainate-binding, human CNS (central nervous system) receptors of the EAA4 (excitatory amino acid) family
Kainate-binding, human CNS (central nervous system) receptors of the EAA4 (excitatory amino acid) family
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机译:EAA4(兴奋性氨基酸)家族的与海藻酸盐结合的人CNS(中枢神经系统)受体
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摘要
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of these receptors of the kainate-binding type of EAA receptors, has now been isolated and the receptor protein characterized. Herein described are recombinant cell lines which produce the EAA receptor as a heterologous membrane-bound product. Also described are related aspects of the invention, which are of commercial significance. Included is use of the cell lines as a tool for discovery of compounds which modulate EAA receptor stimulation.
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