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ANTISENSE OLIGON NUCLEOTIDES INTERFERING WITH THE mRNA CAP ACTIVITY AND INHIBITING THE TRANSLATION
ANTISENSE OLIGON NUCLEOTIDES INTERFERING WITH THE mRNA CAP ACTIVITY AND INHIBITING THE TRANSLATION
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机译:反义寡核苷酸干扰mRNA帽的活性并抑制翻译
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摘要
Compositions and methods for achieving therapeutic treatment of diseases and for regulating gene expression in biological experimental systems via interference with 5' capping of targeted nascent mRNAs are disclosed. Interference with capping is achieved in accordance with preferred embodiments utilizing antisense oligonucleotide compounds which are complementary to the targeted nascent RNA and prevent binding of capping enzyme either via steric interference or by chemical modification of the nascent mRNA.
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