monoclonal antibody against an epitope of a certain class or form of phosphoryliertem tau, the sezernieren hybridoma characteristics, antigenerkennung by these antibodies and their use

摘要

PCT No. PCT/EP95/03032 Sec. 371 Date Mar. 24, 1997 Sec. 102(e) Date Mar. 24, 1997 PCT Filed Jul. 31, 1995 PCT Pub. No. WO96/04309 PCT Pub. Date Feb. 15, 1996The present invention relates to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of a particular subclass or form of phosphorylated tau protein without forming an immunological complex with (i) fetal tau or (ii) biopsy or autopsy derived brain material from patients having died or suffering from diseases in which neurofibrillary tangle (NFT) is not a pathological hallmark. The invention also relates to a process for diagnosing brain diseases involving monoclonal antibodies of the invention. The invention also relates to a region of the tau molecule which is specifically recognized by the monoclonal antibodies of the invention.