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LACTONE-STABILE CAMPTOTHECIN ODER 7 - ETHYL CAMPTOTHECIN - FORMULIERUNG IN DIMETHYLISOSORBID ODER DIMETHYLACETAMID
LACTONE-STABILE CAMPTOTHECIN ODER 7 - ETHYL CAMPTOTHECIN - FORMULIERUNG IN DIMETHYLISOSORBID ODER DIMETHYLACETAMID
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机译:内酯稳定的喜树碱或7-乙基喜树碱在异丁二酸二甲酯或乙二酰胺中的配制
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摘要
Camptothecin (CPT) and 7-ethyl camptothecin (ECPT), are poorly soluble in water. Because of their poor water-solubility, they have not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of tumors. The invention provides a pharmaceutically acceptable formulation in the form of an acidic solution or suspension comprising (1) CPT or ECPT, preponderantly in the desired lactone form (1a') (wherein R is hydrogen or ethyl) and (2) dimethylisosorbide or dimethylacetamide.
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