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by groups of enlarged fluorophore polymers, a hydrophobic and konformativ eingeschrankte microenvironment create
by groups of enlarged fluorophore polymers, a hydrophobic and konformativ eingeschrankte microenvironment create
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机译:通过扩大的荧光团聚合物的组,形成疏水的和已知的微环境
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摘要
Fluorescent conjugates suitable for use in flow cytometry and other biological applications. The fluorescent conjugates comprise an antibody having a polymeric dye bound thereto. The polymeric dye is preferably enhanced by a hydrophobic and conformationally restrictive moiety either bound thereto or in close association therewith. The hydrophobic and conformationally restrictive moiety is preferably derived from a cyclodextrin. The polymeric dye comprises a polymeric entity having signal-generating groups, such as aminostyryl pyridinium dye residues attached thereto. The fluorescent conjugates exhibit exceptional stability characteristics and avoid many of the problems of energy transfer, bio-conjugability, and solubility.
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