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procedures for the extraction of paclitaxel in high yield from paclitaxel enthaltendem material
procedures for the extraction of paclitaxel in high yield from paclitaxel enthaltendem material
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机译:紫杉醇焓提取物中紫杉醇高产提取方法
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摘要
A method of isolating paclitaxel from pactitaxel-containing material that includes the steps of obtaining an acetone mixture of the paclitaxel-containing material, then mixing the acetone mixture with an aqueous solvent to form an aqueous supernatant and a precipitate, wherein the precipitate contains at least 3-times higher paclitaxel content than the paclitaxel extract. The acetone/water precipitation step provides a high yield of highly pure paclitaxel that is suitable for industrial scale isolation using conventional normal-phase silica chromatography steps, and the preparation of pharmaceutical compositions containing paclitaxel.
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