process for the production of s - n, n '- bis (2 - hydroxy - 2 - (hydroxymethyl) ethyl - 5 - (2 - hydroxy) - oxopropyl) amino - 2, 4, 6 - triiodo - 1, 3 - benzdicarboxamid

摘要

A process for the preparation of S-N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-oxopropyl)amino]-2,4,6-triiodo-1,3-benzenedicarboxamide, comprising the reaction of S-(-)-5-[[2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-1,3-benzenedicarboxylic acid dichloride (III) with 2-amino-1,3-propanediol (serinol) without a solvent, followed by hydrolysis of the acetate group.