VARIANT POLYNUCLEOTIDE AND NUCLEIC ACID MOLECULE FOR USE IN GENE DIAGNOSIS OF ABNORMALITY OF DRUG DETOXICATION METABOLISM BY GLUCURONIC ACID CONJUGATION ENZYME 1A9

摘要

PROBLEM TO BE SOLVED: To provide a nucleic acid probe and a primer for use in detecting the abnormality of detoxication metabolism by glucronic acid conjugation enzyme 1A9.;SOLUTION: The nucleic acid molecule is such as to enable detecting such a mutation that a codon encoding the 256th aspartic acid residue of UGT1A9 protein becomes a codon encoding an asparagine residue in the glucronic acid conjugation enzyme 1A9(UGT1A9). This nucleic acid molecule is characterized by containing a polynucleotide encoding a protein having a mutation of the 256th aspartic acid residue to the asparagine residue or a nucleotide fragment hybridizable with a polynucleotide complementary to the above polynucleotide in a protein containing an amino acid sequence shown by the Sequence No.2.;COPYRIGHT: (C)2005,JPO&NCIPI