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Central venous catheter deposited with lipodarubeptide antibiotics to prevent the progression of catheter-related infections
Central venous catheter deposited with lipodarubeptide antibiotics to prevent the progression of catheter-related infections
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机译:中心静脉导管内沉积有脂双糖肽类抗生素,以防止导管相关感染的进展
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摘要
The invention relates to central venous polyurethane catheters with a thin hydrophilic coating loaded with a lipodalbaheptide antibiotic and the method for their preparation. Lipodalbaheptide antibiotics particularly suitable for the preparation of the above mentioned central venous catheters are selected from teicoplanin, its functional derivatives at the C-63 carboxy group, antibiotic A 40926, and its derivatives at the C-63 carboxy group. These catheters are useful to prevent bacterial adherence and colonization and, therefore, to lower the risk of vascular infections in catheterized patients. The method of preparing the catheter of the invention consists in incubating polyurethane catheters coated with a hydrophilic film in an aqueous solution of selected lipodalbaheptide antibiotic.
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