Mice unable to express functional α-4 integrin protein, and methods for analyzing compounds or agents for α-4 integrin protein antagonist activity, and for assessing the efficacy of modulators of VLA-4 receptor signaling activity Gene marker

摘要

Provided herein is a mouse that is unable to express functional alpha-4 integrin protein, and methods for assaying agents for alpha-4 integrin antagonist activity, as well genetic markers for analyzing the efficacy of VLA-4 modulators, and particularly antagonists.