IMPROVED METHOD FOR PRODUCING POLYVALENT PROTEOSOME SUBUNIT VACCINE OBTAINED BY FORMING NON-COVALENT COMPLEX

摘要

PPROBLEM TO BE SOLVED: To provide an improved method for producing polyvalent proteosome vaccine obtained by forming non-covalent complex. PSOLUTION: The process for preparing proteosome amphiphilic determinant vaccine comprises (a) a step of forming a mixture of proteosome, a dialyzable surfactant with an amphiphilic determinant, (b) a step of forming an amphiphilic determinant/proteosome complex by removing the surfactant by treating the mixture by diafiltration or ultrafiltration, (c) a step of monitoring a formation of the amphiphilic determinant/proteosome complex and (d) a step of collecting the amphiphilic determinant/proteosome complex. PCOPYRIGHT: (C)2004,JPO