To Develop Improved Polyvalent Adenovirus Vaccine to Provide a Base for Others Against Viral Agents in Respiratory Illness.

摘要

During the past year the preparation and safety testing of the following potential vaccines have been completed: (1)Adenovirus types 1, 2, 3, 5, 14and 21were prepared as live,oral vaccines and as conventional formalin-inactivated vaccines; (2) The safety testing of potential live parainfluenza vaccines made in RIF-free eggs were completed. (3) Miniature dosage forms suitable for oral administration in young children have been prepared using several adenovirus types and a fluorescene-labeled globulin as model system. (4) Scale-up procedures for producing subunit adenovirus vaccines free of nucleic acids have been studied using types 5and 7. (5) Additional large lots of adenovirus types 4and 7have been prepared for the military. A new formula for improving titer and storage stability has been developed and tested with good results.