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Liposome composition for intracellular delivery of improved therapeutic agents
Liposome composition for intracellular delivery of improved therapeutic agents
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机译:用于细胞内递送改良治疗剂的脂质体组合物
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摘要
A liposomal composition and a method of using the same for achieving intracellular delivery of a liposome-entrapped agent is described. The liposomes are composed of a pH sensitive lipid and include a targeting ligand to direct the liposomes to a target cell. The liposomes also include a stabilizing component, such a polymer-derivatized lipid, where the polymer is attached to the lipid by a releasable linkage. Administration of the liposomes results in cellular internalization and destabilization of the liposome for intracellular delivery of the entrapped agent.
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