Harintonin in high purity and crystalline form, and from natural, synthetic or semi-synthetic sources that allow it to be used in pharmaceutical compositions that are particularly beneficial for the treatment of cancer using oral administration methods A method for preparing halintonin by purification of the crude alkaloid obtained.

摘要

The invention concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n=2 (i.e. harringtonine) or n=3(i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%.