Highly purified and crystalline form of harringtonines their process of preparation by purification of crude alkaloids from natural synthetic or semi-synthetic sources allowing their use for blending in pharmaceutical composition particularly useful for treatment of cancer in using oral mode of administration

摘要

The invention concerns a natural, synthetic or semi-synthetic harringtonines including their tautomeric forms and their salts of the following formula: wherein n2 (i.e. harringtonine) or n3(i.e. homoharringtonine), in which the total content of impurities, possibly including enantiomeric forms, is lower than 1%, and/or the content of the major impurity is lower than 0.9%, and/or the chromatographic assay exhibits a harringtonines content higher than 97.5%. chemistry chemdraw filechemistry mol file