Hydrophobic multiplex compound heparin joining union, the production method and use

摘要

This invention melts in the specific organic solvent, but the hydrophobic multiplex compound heparin joining union (hydrophobic multicomponant heparin conjugates) which does not melt, it is the production method and something regarding use in the aqueous solution. In detail, the hydrophobic multiplex compound heparin joining union which it makes share makes connect the macromolecule and the hydrophobic substance, it is the production method and something regarding use in the heparin. Hydrophobic multiplex compound heparin joining union of this invention, although showing excellent anti- thrombus characteristic, has hydrophobia, because it does not melt in the aqueous solution, can use for the usefulness as all medical equipment or a coating medicine for surface improvement of the artificial organs.